Collect. Czech. Chem. Commun.
1979, 44, 424-428
https://doi.org/10.1135/cccc19790424
7-(3-Substituted amino-2-hydroxypropyl)-8-hydroxymethyltheophyllines
Ladislav Štibrányi, Alfonz Rybár, Lýdia Božeková and Sven Rippa
Drug Research Institute, 801 00 Bratislava
Abstract
N-Substituted derivatives of 7-(3-amino-2-hydroxypropyl)-8-hydroxymethyltheophylline II were prepared by addition of the respective amines to 7-epoxypropyl-8-hydroxymethyltheophylline (I) and alternatively, by alkylation of the potassium salt of 8-hydroxymethyltheophylline (IIIb) with substituted 1-amino-3-chloro-2-propanols. Compounds II were tested on peripheral vasodilating activity in vitro.
