Collect. Czech. Chem. Commun. 1979, 44, 3133-3136

[1-β-Mercaptopropionic acid, 8-α-amino-β-glycylaminopropionic acid]vasopressin. A vasopressin analog with an isopeptide structure in its molecule

Milan Zaorala, Viktor Krchňáka, Jana Škopkováa and Alena Machováb

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute for Pharmacy and Biochemistry, 190 00 Prague 9


[1-β-Mercaptopropionic acid, 8-α-amino-β-glycylaminopropionic acid]vasopressin (II) was prepared by solid-phase peptide synthesis. II has an antidiuretic effect of considerable magnitude (435 I.U./mg) and specificity.