Collect. Czech. Chem. Commun.
1958, 23, 2201-2206
https://doi.org/10.1135/cccc19582201
Mechanism of the cancerostatic action of 6-azauracil and its riboside
V. Habermann and F. Šorm
Crossref Cited-by Linking
- ŜEFERNA I, LOUKOMSKAYA N, KADLEC O, JANKŮ I: The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea-pig to drugs and to coaxial stimulation. Journal of Pharmacy and Pharmacology 2011, 18, 501. <https://doi.org/10.1111/j.2042-7158.1966.tb07917.x>
- Gabrielsen B., Kirsi J. J., Kwong C. D., Carter D. A., Krauth C. A., Hanna L. K., Huggins J. W., Monath T. P., Kefauver D. F., Blough H. A., Rankin J. T., Bartz C. M., Huffman J. H., Smee D. F., Sidwell R. W., Shannon W. M., Secrist J. A.: In vitro and in vivo antiviral (RNA) evaluation of orotidine 5′-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5′-(ethyl methoxyalaninyl)phosphate (a 5′-monophosphate prodrug). Antivir Chem Chemother 1994, 5, 209. <https://doi.org/10.1177/095632029400500402>
- Visek W J, Shoemaker J D: Orotic acid, arginine, and hepatotoxicity. Journal of the American College of Nutrition 1986, 5, 153. <https://doi.org/10.1080/07315724.1986.10720122>
- Visek Willard J.: Arginine and Disease States. The Journal of Nutrition 1985, 115, 532. <https://doi.org/10.1093/jn/115.4.532>
- Rodaway S., Marcus A.: In vivo synthesis of 6-azauridine 5'-triphosphate and incorporation of 6-azauridine into RNA of germinating wheat embryonic axes. Journal of Biological Chemistry 1980, 255, 8402. <https://doi.org/10.1016/S0021-9258(18)43508-9>
- Rada Břetislav, Doskočil Jiři: Azapyrimidine nucleosides. Pharmacology & Therapeutics 1980, 9, 171. <https://doi.org/10.1016/S0163-7258(80)80018-0>
- Keen Brian T., Krass Dennis K., Paudler W. W.: Ethylenimine derivatives of some 1,2,4‐triazines. Journal of Heterocyclic Chem 1976, 13, 807. <https://doi.org/10.1002/jhet.5570130423>
- Elis J., Rašková H.: New indications for 6-azauridine treatment in man. A review. Eur J Clin Pharmacol 1972, 4, 77. <https://doi.org/10.1007/BF00562501>
- Gutová Marcela, Elis Jiřrí, Rašková Helena: Teratogenic effect of 6‐azauridine in rats. Teratology 1971, 4, 287. <https://doi.org/10.1002/tera.1420040304>
- RADA B.: THE EFFECT OF CELL‐FREE EXTRACTS ON THE INHIBITION OF VIRUS MULTIPLICATION BY 6‐AZAURIDINE. Annals of the New York Academy of Sciences 1970, 173, 176. <https://doi.org/10.1111/j.1749-6632.1970.tb53405.x>
- O'Donovan G A, Neuhard J: Pyrimidine metabolism in microorganisms. Bacteriol Rev 1970, 34, 278. <https://doi.org/10.1128/br.34.3.278-343.1970>
- Bauer V., Cˇapek R.: The effects of 6-azauridine on the peripheral nervous system—I. The action on ganglionic transmission. International Journal of Neuropharmacology 1969, 8, 263. <https://doi.org/10.1016/0028-3908(69)90047-1>
- Cˇapek R., Sˇramka M., Janku˚ I.: Electroencephalographic analysis of the 6-azauridine action on the central nervous system. International Journal of Neuropharmacology 1968, 7, 407. <https://doi.org/10.1016/0028-3908(68)90040-3>
- Veselý J., Čihák A., Šorm F.: Biochemical mechanisms of drug resistance IV. Development of resistance to 5‐azacytidine and simultaneous depression of pyrimidine metabolism in leukemic mice. Intl Journal of Cancer 1967, 2, 639. <https://doi.org/10.1002/ijc.2910020625>
- Čihák A., Šorm F.: Metabolic transformations of 5-azaorotate: Cause of marked inhibition of orotidine-5′-phosphate decarboxylase. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 1967, 149, 314. <https://doi.org/10.1016/0005-2787(67)90719-8>
- Hall W.T., Witkus E.R.: Some effects on the ultrastructure of the root meristem of Allium cepa by 6 aza uracil. Experimental Cell Research 1964, 36, 494. <https://doi.org/10.1016/0014-4827(64)90305-2>
- Goldberg Irving H., Rabinowitz Murray: Inhibition of RNA nucleotidyltransferase by 6-azauridine triphosphate. Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects 1963, 72, 116. <https://doi.org/10.1016/0926-6550(63)90319-0>
- Elis J., Janků I.: Zur Pharmakologie des Azauracilribosids. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 1962, 245, 128. <https://doi.org/10.1007/BF00260120>
- Fallon Harold J., Frei Emil, Freireich Emil J.: Correlations of the biochemical and clinical effects of 6-azauridine in patients with leukemia. The American Journal of Medicine 1962, 33, 526. <https://doi.org/10.1016/0002-9343(62)90263-2>
- Kalousek F., Rychlík I., Šorm F.: Inhibition of formation of the acceptor sequence pCpCpA in soluble ribonucleic acid by 6-azauridine-5′-diphosphate. Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects 1962, 61, 368. <https://doi.org/10.1016/0926-6550(62)90137-8>
- Habermann Vlastimil: The effect of 6-azauracil on microorganisms inhibited by chloramphenicol. Biochimica et Biophysica Acta 1961, 49, 204. <https://doi.org/10.1016/0006-3002(61)90884-8>
- Habermann Vlastimil: Elimination by the urine of orotic acid and orotidine in man after application of 6-azauracil. Biochimica et Biophysica Acta 1960, 43, 137. <https://doi.org/10.1016/0006-3002(60)90420-0>
- Brockman R.W., Davis Joan M., Stutts Patricia: Metabolism of uracil and 5-fluorouracil by drug-sensitive and by drug-resistant bacteria. Biochimica et Biophysica Acta 1960, 40, 22. <https://doi.org/10.1016/0006-3002(60)91311-1>
- Handschumacher R.E.: Azauracil Ribonucleoside and Ribonucleotides: Isolation and Chemical Synthesis. Journal of Biological Chemistry 1960, 235, 764. <https://doi.org/10.1016/S0021-9258(19)67935-4>
- Pasternak C.A., Handschumacher R.E.: The Biochemical Activity of 6-Azauridine: Interference with Pyrimidine Metabolism in Transplantable Mouse Tumors. Journal of Biological Chemistry 1959, 234, 2992. <https://doi.org/10.1016/S0021-9258(18)69710-8>